Neuroblastoma (NB), a devastating pediatric cancer originating from neural crest cells crucial for nervous system development, poses a significant therapeutic challenge.Despite chemotherapy being the primary treatment, approximately 70% of high-risk NB cases develop resistance.Autophagy is vital for neuronal development, balance, and differentiatio
The development of erosion features in cuesta relief regions
The cuesta relief is characterized by high slopes, colluvial deposits and intense evolutionary dynamics, making the region especially prone to soil degradation.This study intends to identify how the relief, lithology, and soils influence the occurrence of linear erosion processes of rill erosion, ravines and gullies in the Yoga Mat Spray cuestas en
ACE inhibition attenuates uremia-induced aortic valve thickening in a novel mouse model
Abstract Background We examined whether impaired renal Paddling - Pumps function causes thickening of the aortic valve leaflets in hyperlipidemic apoE-knockout (apoE-/-) mice, and whether the putative effect on the aortic valves could be prevented by inhibiting the angiotensin-converting enzyme (ACE) with enalapril.Methods Thickening of the aortic
The Moves of Indonesian Application Letters
Job application letter is one of many types of written communication.Every context has its own way to write application letter.This article aimed to know the pattern of moves of solicited and unsolicited job application letters, as well as to identify the structure patterns of moves and language used in Indonesian application letters generally.The